*O’Reilly mentored scientists are bolded.

O’Reilly Lab Research at Villanova University

18. Russo, C. M.; Howey, K. G.; O’Reilly, M. C.* ‘Scalable and Chromatography-Free Synthesis of Efflux Pump Inhibitor Phenylalanine Arginine β-Naphthylamide for its Validation in Wild-Type Bacterial Strains.’ ChemMedChem, 2023, 18, e202300128.

17. Fumo, V. M.; Roberts, R. C.; Zhang, J.; O’Reilly, M. C.* ‘Diastereoselective Synthesis of Cyclic Tetrapeptide Pseudoxylallemycin A Illuminates the Impact of Base During Macrolactamization.’ Organic and Biomolecular Chemistry, 2023, 21, 1056-1069.

16. Boyer, Z. W.; Kessler, H.; Brosman, H.; Ruud, K. J.; Falkowski, A. F.; Viollet, C.; Bourne, C. R.; O’Reilly, M. C.* ‘Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of their Antibacterial Structure-Activity Relationships and Mechanism of Action.’ ACS Omega 2022, 7, 37907-37916.

15. Kessler, H.; Russo, C. M.; Fumo, V.; O’Reilly, M. C.* ‘What’s in a Tablet? Extraction and Spectroscopic Identification of Pharmaceutical Unknowns.’ Journal of Chemical Education 2022, 99, 3024-3029.

14. O’Reilly, M. C.*; Stoffregen, S.; Peterson, K.; Maddox, M.; Schrank, C. ‘Discovery-Based Bromination of Alcohols: An Organic Chemistry Experiment Supporting Spectroscopic Analysis and Mechanistic Reasoning.’ Journal of Chemical Education 2021, 98, 3326-3332.


Doctoral and Postdoctoral Research

13. Manson, D. M.; O’Reilly, M. C.; Nyffeler, K. E.; Blackwell, H. E. ‘Design, synthesis, and biochemical characterization of non-native antagonists of the Pseudomonas aeruginosa quorum sensing receptor LasR with nanomolar IC50 values.’ ACS Infectious Diseases 2020, 6, 649-661.

12. O’Reilly, M. C.; Dong, S.; Rossi, F. A.; Karlen, K. M.; Kumar, R. S.; Nair, S. K.; Blackwell, H. E. ‘Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR.’ Cell Chemical Biology 2018, 25, 1128-1139.

11. O’Reilly, M. C.; Blackwell, H. E. ‘Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor.’ ACS Infectious Diseases 2016, 2, 32-38.

10. Senter, T. J.; O’Reilly, M. C.; Chong, K. M.; Sulikowski, G. A.; Lindsley, C. W. ‘A General, Enantioselective Synthesis of N-Alkyl Terminal Aziridines and C2-Functionalized Azetidines via Organocatalysis.’ Tetrahedron Letters 2015, 56, 1276-1279.

9. Scott S. A.; Spencer C. T.; O’Reilly, M. C.; Brown, K. A.; Cho, C.; Jung, J.; Larock, R.; Brown, H. A.; Lindsley, C. W. ‘Discovery of desketoraloxifene analogs as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes.’ ACS Chemical Biology 2015, 10, 421-432.

8. O’Reilly, M. C.; Scott, S. A.; Brown, H. A.; Lindsley, C. W. ‘Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.’ Bioorganic and Medicinal Chemistry Letters.2014, 24, 5553-5557.

7. O’Reilly, M. C.; Oguin III, T. H.; Scott, S. A.; Thomas, P. G.; Locuson, C. W.; Morrison, R. D.; Daniels, J. S.; Brown, H. A.; Lindsley, C. W. ‘Discovery of a highly selective PLD2 inhibitor, VU0468809 (ML395): a new probe with improved physiochemical properties and broad spectrum antiviral activity against influenza strains.’ ChemMedChem. 2014, 9, 2633-2637.

6. Scott, S. A.; Xiang, Y.; Mathews, T. P.; Plumley, H. C.; Myers, D. S.; Armstrong, M. D.; O’Reilly, M. C.; Lindsley, C. W.; Brown, H. A. ‘Regulation of Phospholipase D activity and phosphatidic acid production downstream of the Purinergic (P2Y6) receptor.’ Journal of Biological Chemistry 2013, 288, 20477-20487.

5. O’Reilly, M. C.; Lindsley C. W. ‘A general, enantioselective synthesis of β and γ-fluoroamines.’ Tetrahedron Letters 2013, 54, 3627-3629.

4. O’Reilly, M. C.; Scott, S. A.; Brown, K. A.; Oguin III, T. H.; Thomas, P. G.; Daniels, J. S.; Morrison, R.;  Brown, H. A.; Lindsley, C. W. ‘Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells.’ Journal of Medicinal Chemistry 2013, 56, 2695-2699.

3. O’Reilly, M.C.; Lindsley, C.W. ‘A general, enantioselective synthesis of protected morpholines and piperazines.’ Organic Letters 2012, 14; 2910-2913.

2. O’Reilly, M.C.; Lindsley, C.W. ‘Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N’-protected piperazines via organocatalysis.’ Tetrahedron Letters 2012, 53, 1539-1542.

1. Mullins, R. J.; O’Reilly, M. C. ‘Houben-Hoesch Reaction’ in Name Reactions for Carbocyclic Ring Formations, Li, J. J. John Wiley & Sons, Inc.,  2010, pp 675-687.