The O’Reilly lab uses organic synthesis, medicinal chemistry, and chemical biology to solve problems. Currently, students are working toward (1) the synthesis and biological evaluation of functionalized dihydropyrimidines as antibacterial dihydrofolate reductase inhibitors, (2) the synthesis of cyclic peptide natural products toward understanding their antibacterial activity, and (3) the development of methods toward efficient asymmetric syntheses of saturated biologically relevant heterocycles.
